Resumen
Datos solicitados: Datos genómicos de pacientes con COVID-19 y algunos pacientes sanos (archivos FASTQ de secuenciación masiva (NGS) y DNA-seq o RNA-seq) y datos clínicos
Objetivo del proyecto: Hacer un análisis bioinformático de diferentes grupos de pacientes con COVID-19 para identificar las causas de las distintas respuestas clínicas
Requester
Name: Juan Manuel Luque Sańchez
Institution: Centro Nacional de Biotecnología, Madrid (Spain)
Web: Covid 19 Patgenome
Description of project:
We want to do a bioinformatic analysis of genomic data (DNA/RNA) of different groups of COVID-19 patients with different pathologies vs. Non-COVID-19 patients, to identify the causes of the different clinical response in the patients. We are also planning to do a nutrigenomic study of patients to see the possible influence of nutrition, gene-nutrient interaction and modulation of the epigenome by nutrients related to the clinical response to infection by COVID-19.
Terms of collaboration:
The requester is open to a long-term collaboration, including co-authorship of eventual papers.
Detailed description of data: We need FASTQ files from COVID-19 patients for DNA-seq /NGS analysis (Exome or Whole genome, both are ok) and for RNA-Seq/NGS analysis. We also need the same for some healthy negative controls persons with the same kind of samples (same organ or tissue than samples of COVID-19 patients).
1) Kind of Samples: Blood or another tissue/organ are ok for us, the better sample is lung, but also is good for us several different organs/tissues of the same patient (for example :lung+bowel+other organs in case of autopsies). We prefer more severe clinical cases and deceased.
2) Number of patients: At least 50 patients/FASTQ files. And their respective sample of negative control (not COVID-19)/FASTQ file for each COVID-19 patient.
We prefer anonymized genomic data + clinical data of the same COVID-19 patients (specially age, other diseases of these patients, comorbidities and nutritional data of these patients if it is possible).
Status of ethical approval:
The requester will work with anonymized datasets, and does not need ethical approval from their institution. They are willing to work with the data provider to obtain any necessary ethical approvals to collect the data.
Nota: En caso necesario, Crowdfight COVID-19 puede proporcionar ayuda para el procesamiento, preparación o envío de los datos. Esto incluye asesoramiento técnico, apoyo de expertos en bases de datos, o voluntarios que realicen tareas manuales (organización de datos, etc.).